Price of over 9 000 building blocks was reduced by 50% on average. Selected compounds were discounted by as much as 80%! The products affected by price reduction conform to high quality standards of Enamine and are available from stock. Over 1 500 building blocks from this set are also available for rush delivery in 1g batches. You can download the set of discounted building blocks as SDF, ISIS DB or PDF. Please visit www.enaminestore.com to check current stock availability and order on-line.

Starting from January 2010, Enamine starts offering screening compounds via three separate libraries: Advanced, HTS and Historical collection. Advanced collection will always contain only novel and recently synthesized compounds, thus clients who persistently monitor additions to Enamine stock will spend less time and efforts to find new structural motifs. HTS collection will continue to be an indispensable source of compounds for various screening needs, providing unparalleled choice of diverse chemotypes. Historical collection will contain compounds representing scientific heritage of major regional research groups and institutions, particularly interesting for research programs in agro-chemistry and material science.

A new e-commerce system enabled by eMolecules has been introduced to provide another convenient tool to select and order Enamine's compounds online. The marketplace at enamine.emolecules.com features an intuitive user-friendly interface, familiar to visitors of www.emolecules.com, with full capabilities of e-shop, making shopping for screening compounds easier and faster than ever. The rapid search engine performs searches in our 1.2 million compound database faster than in 1 minute. After desired amounts, packaging and delivery options are set one can securely pay for selected compounds. Fully automated orders processing has been implemented to speed up compounds dispatch. Additional search features such as search by SDF or by a list of SMILES will make routine pursuit a pleasant experience.

Enamine has established an EU-based stock of building blocks. Ordered compound can now be delivered the next business day. The rush deliveries are possible for a selection of the most popular building blocks in 1 g batch size. We plan to expand our service of expedite deliveries to cover more products in the near future.

Our US-based stock is operational since 2007. With introduction of the new stock Enamine fulfills its commitment to become the world's leading supplier of research chemicals.

Enamine Ltd reports significant progress in development of efficient on-line search and ordering system (On-Line Database). The following features have been implemented during 2008 and are available now to visitors of our web-site:

• ultra-fast substructural, similarity and ADME property searches in the pool of  more than 1,200,000 stock structures;
• convenient search for an ID list;
• handy and intuitive user interface;
• instant price calculation for compounds prior to order;
• no registration required to place order on-line;
• accurate and always up-to-date information on stock availability for each substance;
• frequent updates allow swift appearance of new compounds online;
• structures of selected compounds can be downloaded as SDF for future reference.

We make every effort to further improve and evolve our On-Line Database. We are planning to introduce more innovations soon, providing our valued customers with handy tool for their procurement needs. If you would like to suggest a new functionality for On-Line Database, please write to and let us know your opinion.

To review abstracts published in SYNFACTS please follow these links: 3-Formylchromone to Quinoline Interconversion, An Undemanding Synthesis of Thiazolo[4,5-d]pyridines.
We believe that appearance of reviews of articles written by our chemists among summaries of the current most significant chemical works once again demonstrates high grade of Enamine's expertise in synthetic organic chemistry and particularly in chemistry of heterocycles. Also, please check References section of our web-site for updated list of scientific papers published by our researchers within last year.

Enamine informs customers about successful development of efficient one-pot procedure for synthesis of 1,2,3,4-tetrahydroquinoline-3-carboxylic acids (analogues of N-substituted nipecotic acids).
Reaction scheme is shown below:

Transformation of intermediate product proceeds smoothly in situ, isolation and purification of spiro quinoline-diones is not required. Yields of corresponding carboxylic acids vary from 45 to 70%. Existence of compounds demonstrating anticonvulsant, antiepileptic, anti-inflammatory, neuroprotective and neuroregulatoric activities between known derivatives of nipecotic acid makes exploration of these highly bioavailable acids particularly encouraging. Set of relevant compounds available from Enamine stock can be looked up online or found in current databases. Additional information about synthesis of 1,2,3,4-tetrahydroquinoline-3-carboxylic acids will be provided upon .

Enamine Ltd announces public release of the Library for for Fragment Based Drug Discovery (FBDD) . This perfectly crafted product consists of 1200 compounds, strictly conforming to the widely-adopted by drug discovery inductry Astex’s Rule-Of-3. Fragment Library is constructed around more than 300 core cyclic fragments, featuring unique heterocyclic systems available solely from Enamine. Diversity of over 0.8 justifies the fact that the library is truly unsurpassed at chemical space coverage. Every entry of the library has a long series of a analogical screening compounds available from Enamine Screening Collection. These compounds are readily available to a customer to support fast progress from initial fragment identification to the potent hit. Also, as a part of the follow-up service offered by Enamine, building blocks featuring the same fragments can be purchased directly from Enamine stock to rapidly construct custom library around a chosen core.
For detailed description of Enamine Fragment Library please click here.
More information about Enamine Fragment Library is also available upon .

Library of over 150 000 virtual building blocks has been assembled in collaboration with Ukrorgsynthesis Ltd (UORSY). High feasibility of structures from UORSY Library is backed up by the strong expertise and long term experience in synthetic organic chemistry in both Enamine and UORSY. Over 400 validated and rigorously tested procedures based on more than 50 basic chemical transformations has been utilized to create UORSY Library, leading to the highly diverse set of structures. Reactive intermediates presented in UORSY Library can be effectively utilized in parallel synthesis, for rapid hit-to-lead advance in drug discovery or in various conventional synthetic projects. Compounds from UORSY Library can be ordered in standard batches directly from Ukrorgsynthesis Ltd. Usual delivery time is 4-6 weeks. Please download UORSY Library from www.ukrorgsynth.com.

New product focus issue is available - an updated amino acids database.

Enamine Ltd is pleased to announce expansion of the available laboratory space by 200 m² (2150 sq feet).
Three new lab units were set up for normal operations after construction works and renovation. New laboratory units were equipped with modern laboratory furniture provided by Ukrorgsynthesis Ltd and new labware by IKA, Ilmvac, Axis. Laboratories will be occupied by Custom Synthesis Department, further increasing its capabilities.

Today we present a short bulletin about 3-amino-tetrahydrothiophen-1,1-dioxides in our "Product Focus" section. Several types of reagents featuring this popular motif can be ordered from Enamine stock as well as their derivatives suitable for HTS.

Custom weighing service is available at Enamine.

We announce a series of publications highlighting different features of our Building Blocks Database, entitled "Product Focus". This time we would like to draw your attention to the "Enamine chiral building blocks selection", which describes our collection of chiral optically pure compounds.

The growing demand for screening substances during the past years has imposed the need to develop new methods for the fast and efficient generation of novel, diverse chemical compounds. The ease of separation of polymer supported reagents from target compounds makes solid phase synthesis an invaluable tool of discovery in medicinal chemistry. Recently Enamine has established research projects in polymer supported organic and combinatorial chemistry. The projects listed bellow deal with design and synthesis of new tailored polymer supports and reagents as well as highly efficient novel polymeric scavengers.

1. Polymer supported synthesis of potentially biologically active amidines using chromethyl polysterene-divinylbenzene polymer support (PLCH2Cl).
   
2. Application of polymer supported catalysts of hydrolysis reactions.
   
3. Development of versatile three component polymeric scavenging systems for efficient purification of various target compounds.
   
4. Synthesis of polymer supported lead compounds for affinity chromatography studies of their interactions with target proteins.