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Discovery Diversity Sets

Download Discovery Diversity Sets 10 240 compounds SDF
Download Discovery Diversity Sets 50 240 compounds SDF

The success of high throughput screening in finding initial hits heavily depends on quality and novelty of the compound library. Pharma’s understanding of which compounds are desirable and which ones are to be avoided has evolved rapidly since the introduction of Lipinski’s “rule of 5” in 1997. It has been, however, commonly admitted that screening of the compound libraries designed using only appropriate molecular criteria does not guarantee quick and confident progressing hit compounds into leads. The screening libraries must bear an essential degree of novelty, possess contemporary lead-like properties and be built on “live” chemistry that can benefit from novel commercially available building blocks.

Only within 2014-2016, Enamine has synthesized over 430 000 screening compounds for its public catalogue. These substances feature a new structural diversity of Enamine unique building blocks and scaffolds. In an attempt to bring them as fast as possible to drug discovery, we have designed two non-overlapping diversity sets containing 10 240 and 50 160 compounds. These Discovery Diversity Sets (DDS’s) include representative compounds of all three popular screening collections of Enamine – HTS, Advanced, and Premium. The two sets are highly recommended for phenotypic screens and random screening against new, rare as well as popular targets. The hits discovered can be quickly followed with analogues either from stock or from new syntheses as more than 120 000 building blocks are readily available from Enamine’s stock.

Key features:

  • Novel compounds
  • No singletons, 3-5 compounds per cluster
  • 4 912 Bemis-Murcko frameworks (DDS-50)
  • No PAINS, only medchem friendly compounds
  • Express follow-up guaranteed

Ordering information, most popular formats for delivery

Item Catalog No. No of compounds Amount Plates and format
1 DDS-10-Y-0 10 240 One-shot screening,
e.g. 4 µL of 2 mM
DMSO solution
384-well plates (Matrix Cat. No 4312),
320 cpds per plate: first two and last two columns empty
2 DDS-10-Y-50 10 240 50 µL of 10 mM
DMSO solution
384-well plates (Matrix Cat. No 4312),
320 cpds per plate: first two and last two columns empty
3 DDS-10-X-100 10 240 100 µL of 10 mM
DMSO solution
96-well plates (Matrix Cat. No 4919),
80 cpds per plate: first and last columns empty
4 DDS-10-X-300 10 240 300 µL of 10 mM
DMSO solution
96-well plates (Matrix Cat. No 4919),
80 cpds per plate: first and last columns empty
5 DDS-10-1m 10 240 1 mg dry films 0.75 mL microtubes in latch racks
(Matrix Cat. No 4271)
6 DDS-50-Y-0 50 240 One-shot screening,
e.g. 4 µL of 2 mM
DMSO solution
384-well plates (Matrix Cat. No 4312),
320 cpds per plate: first two and last two columns empty
7 DDS-50-Y-50 50 240 50 µL of 10 mM
DMSO solution
384-well plates (Matrix Cat. No 4312),
320 cpds per plate: first two and last two columns empty
8 DDS-50-Y-100 50 240 100 µL of 10 mM
DMSO solution
384-well plates (Matrix Cat. No 4312),
320 cpds per plate: first two and last two columns empty
9 DDS-50-1m 50 240 1 mg dry films 0.75 mL microtubes in latch racks
(Matrix Cat. No 4271)


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