The ability of Enamine to synthesize a large number of screening compounds with high synthesis success rate has formed the concept of a validated chemistry space of Enamine. This concept was the basis for REAL DataBase creation. We conducted thousands of experiments, rigorously choosing appropriate building blocks and reactions with the highest yields. Then, over 30 liquid-phase reactions were optimized to yield individual products in sufficient purity (>90%). Currently our REAL DataBase contains over 1·10⁷ structures of various compounds with synthesis success rate higher than 50% (typically 60-80%) .

The REAL DataBase is highly dynamic. New reactions and building blocks are continuously introduced into the production scheme, resulting in constant growth of the database. At the same time, some structures and sub-libraries are excluded because of an insufficient success rate of their synthesis. That is why it is very important to make a selection from the latest version of the REAL DataBase. On your request, we will prepare a set of compounds which will fit your requirements and selection capabilities. Alternatively, you can download complete current version of REAL DataBase.

There are following choices:

Other selections can be made according to your specific filtering criteria (MW, scaffold type, any ADME parameter, etc.) as well.

Still have questions about REAL DataBase? Please proceed to the FAQ section.

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