Enamine - smart chemistry solutions

REAL Space Navigator: fast and efficient exploration of REAL space

REAL Space Navigator is the world's largest, ultra-fast searchable chemical space developed in collaboration with BioSolveIT. It comprises roughly 650 million compounds today, which will be delivered on demand in less than 4 weeks with an exceptional success rate of 80% and above. This vast resource allows for efficient hit exploration, from finding previously unknown analogues to scaffold hopping. The chemical space is based on more than 100 Enamine synthesis protocols and in-stock building blocks. It provides an escape from availability bias of current stock screening collections towards IP free areas. The average search time in this space is between 1 and 2 minutes on a standard PC. Simply download → install & execute to explore over half a billion molecules for free within less than 5 minutes.


  • yes, the space is virtual but all compounds in it are available on demand
  • with 647 141 139 molecules it is the world's largest, ultra-fast searchable chemical space
  • delivered time: less than 4 weeks, success rate: 80% and above
  • search time 1 to 2 minutes on average for a typical lead
  • exceptional scaffold hopping capabilities allow you to explore IP free areas

Download REAL Space Navigator for your platform (Note that at least 4Gb of main memory are required):

Linux x64 | Windows x64 | macOS

REAL Space Navigator is equipped with a free license for 3 days after the download, allowing you to locate any molecules of interest and place an order. You may download as often as you wish to renew your access. If you are interested in a permanent license, this is available for a fee. Please contact us at

REAL Space Navigator is super-easy to use. Yet, just in case, here is a little bit of help, as well as an introductory deck of slides.

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