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RESEARCH
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2017
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Publications for 2017

The publications listed below are the result of a creative joint work of Enamine chemists and our cooperation partners at ChemBioCenter, The Institute of High Technologies, The Institute of Organic Chemistry and Karlsruhe Institute of Technology (KIT).

Synthesis of N-nitroso CHF2-pyrazolines, and transformation into CHF2-isoxazolines and pyrazoles
Lebed P.; Fenneteau J.; Wu Y.; Cossy J.; Mykhailiuk P.
Eur. J. Org. Chem. 2017, in press

Synthesis of N-nitroso CHF2-pyrazolines, and transformation into CHF2-isoxazolines and pyrazoles
Diphytanoyl lipids as model systems for studying membrane-active peptides
Kara S.; Afonin S.; Babii O.; Tkachenko A. N.; Komarov I. V.; Ulrich A. S.
Biochimica et Biophysica Acta (BBA) - Biomembranes 2017, in press

Diphytanoyl lipids as model systems for studying membrane-active peptides
Conformational Plasticity of the Cell-Penetrating Peptide SAP as Revealed by Solid-State 19F-NMR and Circular Dichroism Spectroscopies
Afonin S.; Kubyshkin V.; Mykhailiuk P. K.; Komarov I. V.; Ulrich A. S.
J. Phys. Chem. B 2017, in press

Conformational Plasticity of the Cell-Penetrating Peptide SAP as Revealed by Solid-State <sup>19</sup>F-NMR and Circular Dichroism Spectroscopies
A peptidyl-prolyl model study: How does the electronic effect influence the amide bond conformation?
Mykhailiuk P. K.; Kubyshkin V.; Bach T.; Budisa N.
J. Org. Chem. 2017, in press

A peptidyl-prolyl model study: How does the electronic effect influence the amide bond conformation?
Difluoromethyl nitril oxide (CF2HCNO): overseen chemical reagent
Khutoryanskiy A.; Chalyk B.; Borysko P.; Kondratiuk A.; Mykhailiuk P.
Eur. J. Org. Chem. 2017, in press

1-Substituted 2-azaspiro[3.3]heptanes: overseen motifs for drug discovery
1-Substituted 2-Azaspiro[3.3]heptanes: Overlooked Motifs for Drug Discovery
Kirichok A. A.; Shton I.; Kliachyna M.; Pishel I.; Mykhailiuk P. K.
Angew. Chem. Int. Ed. 2017, in press

1-Substituted 2-azaspiro[3.3]heptanes: overseen motifs for drug discovery
Synthesis of 6-azaspiro[4.3]alkanes: innovative scaffolds for drug discovery
Chalyk B.; Isakov A.; Butko M.; Hrebeniuk K.; Savych O.; Kucher O.; Gavrilenko K.; Druzhenko T.; Yarmolchuk V.; Zozulya S.; Mykhailiuk P.
Eur. J. Org. Chem. 2017, in press

Synthesis of 6-azaspiro[4.3]alkanes: innovative scaffolds for drug discovery
Synthesis of functionalized 4-fluoropyridazines
Feraldi-Xypolia A.; Fredj G.; Tran G.; Tsuchiya T.; Vors J.-P.; Mykhailiuk P.; Gomez Pardo D.; Cossy J.
Asian J. Org. Chem. 2017, in press

Synthesis of functionalized 4-fluoropyridazines
An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates
Sokolenko Y. M.; Ostapchuk E. N.; Artemenko A.; Grygorenko O. O.
Synthesis 2017, in press

An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates
Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR
Grage S. L.; Sani M.-A., Cheneval O.; Henriques S. T.; Schalck C.; Heinzmann R.; Mylne J. S.; Mykhailiuk P. K.; Afonin S.; Komarov I. V.; Separovic F.; Craik D. J.; Ulrich A. S.
Biophys. J. 2017, 112 (4), 630–642

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR
CF3S(O)n-containing enaminones as precursors for the synthesis of pyrimidine-4(3H)-ones
Sokolenko L. V.; Yagupolskii Y. L.; Kumanetska L. S.; Marrot J.; Magnier E.; Lipetskij V. O.; Kalinin I. V.
Tetrahedron Lett. 2017, 58 (13), 1308–1311

CF3S(O)n-containing enaminones as precursors for the synthesis of pyrimidine-4(3H)-ones
Synthesis of Fluorinated Oxazoles by Oxidative Cyclization of Fluorinated Enamides
Shishlyk O. S.; Shcherbatiuk A. V.; Iminov R. T.; Tverdokhlebov A. V.; Tolmachev A. A.; Mykhailiuk P. K.; Biitseva A. V.
J. Fluorine Chem. 2017, 196, 88-97


Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF3O-containing analogue of natural lipophilic amino acids
Kondratov I. S.; Logvinenko I. G.; Tolmachova N. A.; Morev R. N.; Kliachyna M. A.; Clausen F.; Daniliuc C. G.; Haufe G.
Org. Biomol. Chem. 2017, 15, 672-679


Synthesis of 3-oxadiazolyl/triazolyl morpholines: Novel scaffolds for drug discovery
Tereshchenko A. D.; Myronchuk J. S.; Leitchenko L. D.; Knysh I. V.; Tokmakova G. O.; Litsis O. O.; Tolmachev A.; Liubchak K.; Mykhailiuk P.
Tetrahedron 2017, 73 (6), 750–757


Synthesis of CF2H-pyrazolines by [3+2]-cycloaddition between CF2HCHN2 and electron-deficient alkenes
Li J.; Yu X.-L.; Cossy J.; Lv S.-Y.; Zhang H.-L.; Su F.; Hai L.; Mykhailiuk P.; Wu Y.
Eur. J. Org. Chem. 2017, 2, 266-270


Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835
Krasavin M.; Lukin A.; Bagnyukova D.; Zhurilo N.; Golovanov A.; Zozulya S.; Zahanich I.; Moore D.; Tikhonova I. G.
Eur. J. Med. Chem. 2017, 127, 357-368




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