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RESEARCH
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2017
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Publications for 2017

The publications listed below are the result of a creative joint work of Enamine chemists and our cooperation partners at ChemBioCenter, The Institute of High Technologies, The Institute of Organic Chemistry and Karlsruhe Institute of Technology (KIT).

Synthesis of functionalized 4-fluoropyridazines
Feraldi-Xypolia A.; Fredj G.; Tran G.; Tsuchiya T.; Vors J.-P.; Mykhailiuk P.; Gomez Pardo D.; Cossy J.
Asian J. Org. Chem. 2017, in press

Synthesis of functionalized 4-fluoropyridazines
An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates
Sokolenko Y. M.; Ostapchuk E. N.; Artemenko A.; Grygorenko O. O.
Synthesis 2017, in press

An Approach to 3-Oxa-7-azabicyclo[3.3.0]octanes – Bicyclic Morpholine Surrogates
Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR
Grage S. L.; Sani M.-A., Cheneval O.; Henriques S. T.; Schalck C.; Heinzmann R.; Mylne J. S.; Mykhailiuk P. K.; Afonin S.; Komarov I. V.; Separovic F.; Craik D. J.; Ulrich A. S.
Biophys. J. 2017, 112 (4), 630–642

Orientation and Location of the Cyclotide Kalata B1 in Lipid Bilayers Revealed by Solid-State NMR
CF3S(O)n-containing enaminones as precursors for the synthesis of pyrimidine-4(3H)-ones
Sokolenko L. V.; Yagupolskii Y. L.; Kumanetska L. S.; Marrot J.; Magnier E.; Lipetskij V. O.; Kalinin I. V.
Tetrahedron Lett. 2017, 58 (13), 1308–1311

CF3S(O)n-containing enaminones as precursors for the synthesis of pyrimidine-4(3H)-ones
Synthesis of Fluorinated Oxazoles by Oxidative Cyclization of Fluorinated Enamides
Shishlyk O. S.; Shcherbatiuk A. V.; Iminov R. T.; Tverdokhlebov A. V.; Tolmachev A. A.; Mykhailiuk P. K.; Biitseva A. V.
J. Fluorine Chem. 2017, 196, 88-97


Synthesis and physical chemical properties of 2-amino-4-(trifluoromethoxy)butanoic acid - a CF3O-containing analogue of natural lipophilic amino acids
Kondratov I. S.; Logvinenko I. G.; Tolmachova N. A.; Morev R. N.; Kliachyna M. A.; Clausen F.; Daniliuc C. G.; Haufe G.
Org. Biomol. Chem. 2017, 15, 672-679


Synthesis of 3-oxadiazolyl/triazolyl morpholines: Novel scaffolds for drug discovery
Tereshchenko A. D.; Myronchuk J. S.; Leitchenko L. D.; Knysh I. V.; Tokmakova G. O.; Litsis O. O.; Tolmachev A.; Liubchak K.; Mykhailiuk P.
Tetrahedron 2017, 73 (6), 750–757


Synthesis of CF2H-pyrazolines by [3+2]-cycloaddition between CF2HCHN2 and electron-deficient alkenes
Li J.; Yu X.-L.; Cossy J.; Lv S.-Y.; Zhang H.-L.; Su F.; Hai L.; Mykhailiuk P.; Wu Y.
Eur. J. Org. Chem. 2017, 2, 266-270


Polar aromatic periphery increases agonist potency of spirocyclic free fatty acid receptor (GPR40) agonists inspired by LY2881835
Krasavin M.; Lukin A.; Bagnyukova D.; Zhurilo N.; Golovanov A.; Zozulya S.; Zahanich I.; Moore D.; Tikhonova I. G.
Eur. J. Med. Chem. 2017, 127, 357-368




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