The real benefits of Fragment-Based Drug Discovery (FBDD) such as low entry costs and ease of generating leads can only be developed with the right high quality tool – a fragment set. It can furnish desired number of hits, at the same time remaining small in size (200 - 3 000 compounds) hence not requiring significant investment. The fragment library design is dictated by the screening technique to be employed and is done through rigorous selection of high quality compounds. Besides chemical purity, stability and solubility criteria it’s essential to pick the representatives of as many molecular clusters as possible.

Enamine’s collection of screening compounds and building blocks is known to be the largest in the world, exceeding 2.2 M substances and it can therefore yield the most diverse screening sets.

• Ro3 Fragment Library - 45 000 compounds
• Golden Fragment Library - 1 700 compounds
• sp³ Rich Fragment Libraries - 14 200 compounds
• PPI Fragment Library - 3 500 compounds
• Fluorinated Fragment Library - 2 100 compounds
• Brominated Fragment Library - 1 200 compounds
• Covalent Fragment Libraries - 3 000 compounds
• Essential Fragment Library - 190 compounds
• Single Pharmacophore Fragments - 3 200 compounds
• Carboxylic Acid Fragment Library - 4 300 compounds
• Custom Set - cherry-pick from over 2.2 M compounds

Most of our fragments are novel and exclusive only to us so that your FBDD will not repeat path of your predecessors and produce new original leads.

Z1198176430 Golden Fragment Library confirmed solubility at 1-2 mM high framework diversity	Z1127205115 Essential Fragment Library water solubility at 1mM confirmed stability in water buffer	Z1860991860 Single Pharmacophore Library Small & Smart approach

Z1954802871 Covalent Fragment Libraries specially designed and synthesized	Z1225460101 Fluorinated Fragments confirmed water solubility at 1mM specified F19 NMR shifts

You can download SDF’s of our fragment libraries on the corresponding product pages or on the download page. Please feel free to contact us at . We welcome cherry-picking from all libraries and can further assist your selection.