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Premium Collection

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Enamine Premium Collection contains over 107 029 compounds having most favorable molecular properties (high Fsp3, low logP and MW). They have been synthesized in our lead-oriented synthesis program. Remarkable success achieved by Enamine in synthesizing novel lead-like compound libraries is explained by usage of robust and sustainable chemical methodology which concept is based on development of the building block inventory. While designing new molecular scaffolds we not only address the issue of molecular properties and pharmacophore composition of the derived compounds but also the cost factor related to follow-up of the found hits. Owing to the high degree of chemistry validation and availability of the analogous building blocks from our catalogue the hit-to-lead process runs fast and smoothly.

Z1625698406
MW 347.4
ClogP 1.19

Z1136426268, racemic
MW 349.4
ClogP 2.02

Z1139491269
MW 343.4
ClogP 0.91

Figure 1. Examples of compounds from Premium collection.

Figure 2. Distribution of the compounds from Premium Collection by selected molecular parameters.



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