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The publications listed below are the result of a creative joint work of Enamine chemists and our cooperation partners at
ChemBioCenter, The Institute of High Technologies, The Institute of Organic Chemistry and Karlsruhe Institute of Technology (KIT). 2012 Design and Synthesis of Polycyclic Imidazole-Containing N- Heterocycles based on C=H Activation/Cyclization Reactions Iaroshenko, V. O.; Ostrovskyi, D.; Miliutina, M.; Maalik, A.; Villinger, A.; Tolmachev, A.; Volochnyuk, D. M.; Langer, P. Adv Synth Catal 2012, 354, 2495-2503.   An Improved Synthesis of 2-, 3-, and 4-(Trifluoromethyl)cyclohexylamines Alekseenko, A. N.; Denis, K.; Lukin, O.; Mykhailiuk, P. K.; Shishkin, O. V.; Pustovit, Y. M. Synthesis 2012, 44, 2739-2742. An Efficient and Safe Method for the Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropylamine. Yarmolchuk, V. S.; Bezdudny, A. V.; Tolmacheva, N. A.; Lukin, O.; Boyko, A. N.; Chekotylo, A.; Tomachev, A. A.; Mykhailiuk, P. K. Synthesis 2012, 44, 1152-1154. A Facile Synthesis of Isomeric C-(2,2,2-Trifluoroethyl)anilines. Trofymchuk, S.; Bezdudny, A. V.; Pustovit, Y. M.; Lukin, O.; Boyko, A. N.; Chekotylo, A.; Tomachev, A. A.; Mykhailiuk, P. K. Synthesis 2012, 44, 1974-1976. A Facile Synthesis of 1,3-Thiazole-4-sulfonyl Chlorides. Demydchuk, B. A.; Kondratyuk, K. M.; Korniyenko, A. N.; Brovarets, V. S.; Vasylyshyn, R. Y.; Tolmachev, A.; Lukin, O. Synth. Commun. 2012, 42, 2866-2875. Regioselective Reactions of Ethyl (4,5-Dihydrofuran-3-yl)-2-oxoacetate and Ethyl 2-(3,4-Dihydro-2H-pyran-6-yl)-2-oxoacetate with 1-Unsubstituted Aminoazoles. Stepaniuk, O. O.; Matvienko, V. O.; Kondratov, I. S.; Shishkin, O. V.; Volochnyuk, D. M.; Mykhailiuk, P. K.; Tolmachev, A. A. Synthesis 2012, 44, 895-902. Synthesis of condensed tetrahydroimidazo[1,2-a]quinazoline-1,5-dione derivatives. Iminov, R. I.; Tverdokhlebov, A. V.; Tolmachev, A. A.; Volovenko, Y. M.; Shishkina, S. V.; Shishkin, O. V. Tetrahedron 2012, 68, 3098-3102. 2,3-Unsubstituted chromones and their enaminone precursors as versatile reagents for the synthesis of fused pyridines. Iaroshenko, V. O.; Mkrtchyan, S.; Gevorgyan, A.; Miliutina, M.; Villinger, A.; Volochnyuk, D. M.; Sosnovskikh, V. Ya.; Langer, P. Org. Biomol. Chem. 2012, 10, 890-894. “Reported, but Still Unknown.” A Closer Look into 3,4-Bis- and 3,4,5-Tris(trifluoromethyl)pyrazoles. Gerus, I. I.; Mironetz, R. X.; Kondratov, I. S.; Bezdudny, A. V.; Dmytriv, I. V.; Shishkin, O. V.; Starova, V. S.; Zaporozhets, O. A.; Tolmachev, A. A.; Mykhailiuk, P. K. J. Org. Chem. 2012, 77, 47-56. 2011 A one-pot, non-catalytic approach to 1,2,4-benzothiadiazine-1,1-dioxides. Cherepakha, A.; Kovtunenko, V.O.; Tolmachev, A.; Lukin, O. Tetrahedron 2011, 67, 6233-6239. An Entry into Hexahydro-2H-thieno[2,3-c]pyrrole-1,1-Dioxide Derivatives. Yarmolchuk, V.S.; Mukan, I.L.; Grygorenko, O.O.; Tolmachev, A.A.; Shishkina, S.V.; Shishkin, O.V.; Komarov, I.V. J. Org. Chem. 2011, 76, 7010-7016. Facile Synthesis of 4H-1,2,4-Benzothiadiazine-1,1-dioxides. Cherepakha, A.; Kovtunenko, V. O.; Tolmachev, A.; Lukin, O.; Nazarenko, K. G. Synth. Commun. 2011, 41, 1977-1989. 3-(Dichloroacetyl)chromone; A New Building Block for the Synthesis of Formylated Purine Isosteres: Design and Synthesis of Fused alpha-(Formyl)pyridines. Iaroshenko, V. O.; Mkrtchyan, S.; Ghazaryan, G.; Hakobyan, A.; Maalika, A.; Supea, L.; Villinger, A.; Tolmachev, A.; Ostrovskyi, D.; Sosnovskikh, V. Y.; Ghochikyanc, T. V.; Langer, P. Synthesis 2011, 469-479. 2010 3-Methoxalylchromone - a novel versatile reagent for the regioselective purine isostere synthesis. Mkrtchyan, S.; Iaroshenko, V. O.; Dudkin, S.; Gevorgyan, A.; Vilches-Herrera, M.; Ghazaryan, G.; Volochnyuk, D. M.; Ostrovskyi, D.; Ahmed, Z.; Villinger, A.; Sosnovskikh, V. Ya.; Langer, P. Org. Biomol. Chem. 2010, 8, 5280–5284. 3-Formylchromones, Acylpyruvates, and Chalcone as Valuable Substrates for the Syntheses of Fused Pyridines. Iaroshenko, O.; Mkrtchyan, S.; Volochnyuk, D. M.; Peter Langer, P.; Sosnovskikh, V. Ya.; Ostrovskyi, D.; Dudkin, S.; Kotljarov, A. V.; Miliutina, M.; Savych, I.; Tolmachev, A. A. Synthesis 2010, 2749–2758. An Efficient Synthesis of 6-Nitro- and 6-Amino-3H-imidazo[4,5-b]pyridines by Cyclocondensation of 1-Substituted 1H-Imidazol-5-amines with 3-Nitro-4H-chromen-4-one. Ostrovskyi, D.; Iaroshenko, V. O.; Petrosyan, A.; Dudkin, S.; Ali, I.; Villinger, A.; Tolmachev, A.; Langer, P. Synlett 2010, 2299–2303. Approach to the Library of Fused Pyridine-4-carboxylic Acids by Combes-Type Reaction of Acyl Pyruvates and Electron-Rich Amino Heterocycles. Volochnyuk, D. M.; Ryabukhin, S. V.; Plaskon, A. S.; Dmytriv, Y. V.; Grygorenko, O. O.; Mykhailiuk, P. K.; Krotko, D. G.; Pushechnikov, A.; Tolmachev, A. A. J. Comb. Chem. 2010, 12, 510–517. Regioselective Synthesis of Novel Perfluoroalkylated Fused Pyridines and 3-(Aminomethylene)thiochroman-4-ones from 3-(Perfluoroalkanoyl)thiochromenones and Amines. Kotljarov, A.; Sevenard, D. V.; Iaroshenko, V. O.; Irgashev, R. A.; Volochnyuk, D. M.; Langer, P.; Tolmachev, A. A.; Sosnovskikh, V. Y. Synthesis, 2010, 671-677. Recyclization reactions of 2-(1-benzoylpyrrolidin-2-ylidene)malononitrile. Shvidenko, K. V.; Nazarenko, K. G.; Shvidenko, T. I.; Tolmachev, A. A. Chem. Heterocycl. Comp. 2010, 46, 56-60. Synthesis of bridged 1,4-diazepane derivatives via Schmidt reactions. Mityuk, A. P.; Denisenko, A. V.; Dacenko, O. P.; Grygorenko, O. O.; Mykhailiuk, P. K.; Volochnyuk, D. M.; Tolmachev, A. A. Tetrahedron Lett. 2010, 51, 1790-1792. Synthesis of Chromeno[3,4-b]pyrrol-4(3H)-ones by Cyclocondensation of 1,3-Bis(trimethylsilyloxy)buta-1,3-dienes with 4-Chloro-3-nitrocoumarin. Fatunsin, O.; Iaroshenko, V. O.; Dudkin, S.; Shkoor, M.; Volochnyuk, D.; Gevorgyan, A.; Langer, P. Synlett 2010, 1533-1535. 2009 Synthesis of New 2-Thio-[1,2,4]triazolo[1,5-c]quinazoline Derivatives and Its Antimicrobial Activity. Antipenko, L.; Karpenko, A.; Kovalenko, S.; Katsev, A.; Komarovska-Porokhnyavets, E.; Novikov, V.; Chekotilo, A. Chem. Pharm. Bull. 2009 57, 580-585. Synthesis of new polyfunctional 5,6,7,8-tetrahydroimidazo-[1,5-c]pyrimidin-5-ones by the aza-Wittig reaction followed by intramolecular cyclization and 1,3-prototropic shift. Lebed', P.; Kos, P.; Polovinko, V.; Tolmachev, A.; Vovk, M. Russ. J. Org. Chem. 2009 45, 921-927. 4-Fluoro-2,4-methanoproline. Tkachenko, A. N.; Radchenko, D. S.; Mykhailiuk, P. K.; Grygorenko, O. O.; Komarov, I. V. Org. Lett. 2009 11, 5674-5676. 2008 2-(trifluoroacetyl)imidazoles, 2-trifluoroacetyl-1,3-thiazoles, and 2-trifluoroacetyl-1,3-oxazoles. Khodakovskiy, P. V.; Volochnyuk, D. M.; Panov, D. M.; Pervak, I. I.; Zarudnitskii, E. V.; Shishkin, O. V.; Yurchenko, A. A.; Shivanyuk, A.; Tolmachev, A. A. Synthesis 2008, 948-956. Synthesis of 1,4-benzothiazin-2-yl derivatives of 1,3-dicarbonyl compounds and benzothiazinone spiro derivatives by the reaction of 2-chloro-1,4-benzothiazin-3-ones with 'push-pull' enamines. Nazarenko, K. G.; Shtil, N. A.; Buth, S. A.; Chernega, A. N.; Lozinskii, M. O.; Tolmachev, A. A. Tetrahedron 2008, 64, 4478-4485. Simple and convenient synthesis of 2,3,4,5-tetrahydro-1,5-dioxopyrrolo[1,2-a]quinazoline-3a(1H)-carboxylic acids in multi-gram scale. Iminov, R. T.; Tverdokhlebov, A. V.; Tolmachev, A. A.; Volovenko, Y. M.; Kostyuk, A. N.; Chernega, A. N.; Rusanov, E. B. Heterocycles 2008, 75, 1673-1680. Synthesis of thiazolo[4,5-d]pyridines. Laroshenko, V. O.; Volochnyuk, D. M.; Kryvokhyzha, N. V.; Martyloga, A.; Sevenard, D. V.; Groth, U.; Brand, J.; Chernega, A. N.; Shivanyuk, A. N.; Tolmachev, A. A. Synthesis 2008, 2337-2346. Facile one-pot synthesis of 1,2,3,4-tetrahydroquinoline-3-carboxylic acids and their heterocyclic analogs. Ryabukhin, S. V.; Plaskon, A. S.; Volochnyuk, D. M.; Pipko, S. E.; Tolmachev, A. A. Synth. Commun. 2008, 38, 3032-3043. DOI: 10.1055/s-2008-1067214 Tverdokhlebov, A. V.; Andrushko, A. P.; Tolmachev, A. A.; Shishkina, S. V.; Shishkin, O. V. Synthesis 2008, 2701-2706. Recyclization of 2-(3,6-diaryl-2,5-dihydropyridazin-4-yl)-1h-benzimidazoles to 2-[(3,5-diarylpyrazol-4-yl)methyl]-1h-benzimidazoles. Dzvinchuk, I. B.; Chernega, A. N.; Lozinskii, M. O.; Tolmachev, A. A. Chem. Heterocycl. Comp.2008, 44, 682-689. Synthesis and Properties of λ5-Phosphinines and λ5-Azaphosphinines. Kostyuk, A. N.; Svyashchenko, Yu. V.; Volochnyuk, D, M.; Sibgatulin, D. A.; Pinchuk, A. M. Phosphorus, Sulfur, and Silicon and the Related Elements 2008, 183, 558-560. 2007 Polyfluoromethyl-containing amino acids - new structures and synthetic strategies. Gerus, I.; Pustovit, Y.; Shaitanova, E.; Tolmachova, N.; Alexeenko, A.; Trofymchuk, S.; Tolmachev, A.; Kukhar, V. Amino Acids 2007, 33, LXIII. In Silico Design of Protein Kinase Inhibitors: Successes and Failures. Dubinina, G. G.; Chupryna, O. O.; Platonov, M. O.; Borisko, P. O.; Ostrovska, G. V.; Tolmachov, A.; Shtil, A. A. Anti-Cancer Agents in Medicinal Chemistry 2007, 7, 171-188. Conformational restriction as a design concept for amino acids and peptidomimetics. Komarov, I. V.; Grygorenko, O. O.; Radchenko, D. S.; Gvozdovska, N. P.; Tolmachev, A. A. Amino Acids 2007, 33, XV. A new approach to pyrazino[2,1-b]quinazolines and pyrazino[1,2-a]thieno[3,2-d]pyrimidines. Kulik, S. N.; Kobko, A. S.; Tolmachev, A. A.; Tverdokhlebov, A. V.; Shishkin, O. V.; Chernega, A. N. Synthesis 2007, 1503-1508. N-substituted ureas and thioureas in Biginelli reaction promoted by chlorotrimethylsilane: Convenient synthesis of N1-alkyl-, N1-aryl-, and N1,N3-dialkyl-3,4-dihydropyrimidin-2(1H)-(thi)ones. Ryabukhin, S. V.; Plaskon, A. S.; Ostapchuk, E. N.; Volochnyuk, D. M.; Tolmachev, A. A. Synthesis 2007, 417-427. A one-step fusion of 1,3-thiazine and pyrimidine cycles. Ryabukhin, S. V.; Plaskon, A. S.; Ostapchuk, E. N.; Volochnyuk, D. M.; Shishkin, O. V.; Shivanyuk, A. N.; Tolmachev, A. A. Org. Lett. 2007, 9, 4215-4218.
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