The publications listed below are the result of a creative joint work of Enamine chemists and our cooperation partners at ChemBioCenter, The Institute of High Technologies, and The Institute of Organic Chemistry.

Zadorozhny, A. V. Synthesis of substituted 4-aminothieno[2,3-d]-,4-aminothieno[3,2-d]- and 4-aminothieno[3,4-d]pyrimidines Chem Heterocycl Comp. 2012, 48, 1028-1032.

Ryabukhin, S. V.; Panov, D. M.; Plaskon, A. S.; Tolmachev, A. A.; Smaliy, R. V. Application of chlorotrimethylsilane in Pictet–Spengler reaction  Monatsh Chem 2012, 143, 1507-1517.

Ryabukhin, S. V.; Panov, D. M.; Plaskon, A. S.; Grygorenko, O. O. Approach to the Library of 3-Hydroxy-1,5-dihydro-2H-pyrrol-2-ones through a Three-Component Condensation ACS Comb Sci 2012, 14, 631-635.

Ryabukhin, S. V.; Panov, D. M.; Plaskon, A. S.; Chuprina, A.; Pipko, S. E.; Tolmachev, A. A.; Shivanyuk, A. N. Combinatorial synthesis of chemical building blocks 1. Azomethines Mol Divers 2012, 16, 625-637.

Ryabukhin, S. V.; Naumchik, V. S.; Grygorenko, O. O.; Tolmachev, A. A. Chlorotrimethylsilane-Promoted Condensation of Ketones and Aminoazoles J Heterocyclic Chem 2012, 49, 1147-1150.

Ryabukhin, S. V.; Granat, D. S.; Plaskon, A. S.; Shivanyuk, A. N.; Tolmachev, A. A.; Volovenko, Y. M. High Throughput Synthesis of Extended Pyrazolo[3,4-d]dihydropyrimidines ACS Comb Sci 2012, 14, 465-470.

Nechayev, M. A.; Gorobets, N. Y.; Borisov, A. V.; Kovalenko, S. M.; Tolmachev, A. A. The synthesis of low molecular weight pyrrolo[2,3-c]pyridine-7-one scaffold Mol Divers 2012, 16, 749-757.

Mityuk, A. P.; Denisenko, A. V.; Grygorenko, O. O.; Tolmachev, A. A. Synthesis of dihydro-2H-pyran-3(4H)-one Arkivoc 2012, 226-230.

Liubchak, K.; Tolmachev, A.; Grygorenko, O. O.; Nazarenko, K. An approach to alicyclic ring-fused xanthines Tetrahedron 2012, 68, 8564-8571.

Kubyshkin, V. S.; Mykhailiuk, P. K.; Afonin, S.; Ulrich, A. S.; Komarov, I. V. Incorporation of cis- and trans-4,5-Difluoromethanoprolines into Polypeptides Org Lett 2012, 14, 5254-5257.

Iaroshenko, V. O.; Ostrovskyi, D.; Miliutina, M.; Maalik, A.; Villinger, A.; Tolmachev, A.; Volochnyuk, D. M.; Langer, P. Design and Synthesis of Polycyclic Imidazole-Containing N- Heterocycles based on C=H Activation/Cyclization Reactions Adv Synth Catal 2012, 354, 2495-2503.

Grygorenko, O. O.; Prytulyak, R.; Volochnyuk, D. M.; Kudrya, V.; Khavryuchenko, O. V.; Komarov, I. V. Focused enumeration and assessing the structural diversity of scaffold libraries: conformationally restricted bicyclic secondary diamines Mol Divers 2012, 16, 477-487.

Alekseenko, A. N.; Denis, K.; Lukin, O.; Mykhailiuk, P. K.; Shishkin, O. V.; Pustovit, Y. M. An Improved Synthesis of 2-, 3-, and 4-(Trifluoromethyl)cyclohexylamines Synthesis 2012, 44, 2739-2742.

Yarmolchuk, V. S.; Bezdudny, A. V.; Tolmacheva, N. A.; Lukin, O.; Boyko, A. N.; Chekotylo, A.; Tomachev, A. A.; Mykhailiuk, P. K. An Efficient and Safe Method for the Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropylamine. Synthesis 2012, 44, 1152-1154.

Trofymchuk, S.; Bezdudny, A. V.; Pustovit, Y. M.; Lukin, O.; Boyko, A. N.; Chekotylo, A.; Tomachev, A. A.; Mykhailiuk, P. K. A Facile Synthesis of Isomeric C-(2,2,2-Trifluoroethyl)anilines. Synthesis 2012, 44, 1974-1976.

Demydchuk, B. A.; Kondratyuk, K. M.; Korniyenko, A. N.; Brovarets, V. S.; Vasylyshyn, R. Y.; Tolmachev, A.; Lukin, O. A Facile Synthesis of 1,3-Thiazole-4-sulfonyl Chlorides. Synth. Commun. 2012, 42, 2866-2875.

Tymtsunik, A. V.; Bilenko, V. A.; Kokhan, S. O.; Grygorenko, O. O.; Volochnyuk, D. M.; Komarov, I. V. 1-Alkyl-5-((di)alkylamino) Tetrazoles: Building Blocks for Peptide Surrogates. J. Org. Chem. 2012, 77, 1174-1180.

Tkachenko, A. N.; Radchenko, D. S.; Mykhailiuk, P. K.; Shishkin, O. V.; Tolmachev, A. A.; Komarov, I. V. Exploiting the Addition of Trimethyl(trifluoromethyl)silane to Functionalized N-Benzylimines for the Preparation of Two Novel x-Trifluoromethyl x-Amino Acids. Synthesis 2012, 44, 903-908.

Geraschenko, O. V.; Khodakovskiy, P. V.; Shivanyuk, A. N.; Shishkin, O. V.; Mykhailiuk, P. K.; Tolmachev, A. A. Easy Synthesis of Novel 4-Azolylpyridazin-3-ones. Synthesis 2012, 44, 1263-1267.

Shevchuk, N. S.; Liubchak, K.; Nazarenko, K. G.; Yurchenko, A. A.; Volochnyuk, D. M.; Grygorenko, O. O.; Tolmachev, A. A. A Convenient Synthesis of (1H-Azol-1-yl)piperidines. Synthesis 2012, 44, 2041-2048.

Stepaniuk, O. O.; Matvienko, V. O.; Kondratov, I. S.; Shishkin, O. V.; Volochnyuk, D. M.; Mykhailiuk, P. K.; Tolmachev, A. A. Regioselective Reactions of Ethyl (4,5-Dihydrofuran-3-yl)-2-oxoacetate and Ethyl 2-(3,4-Dihydro-2H-pyran-6-yl)-2-oxoacetate with 1-Unsubstituted Aminoazoles. Synthesis 2012, 44, 895-902.

Plaskon, A. S.; Grygorenko, O. O.; Ryabukhin, S. V. Recyclizations of 3-formylchromones with binucleophiles. Tetrahedron 2012, 68, 2743-2757.

Tymtsunik, A. V.; Bilenko, V. A.; Ivon, Y. M.; Grygorenko, O. O.; Komarov, I. V. Synthesis of a novel Boc-protected cyclopropane-modified proline analogue. Tetrahedron Lett. 2012, 53, 3847-3849.

Iminov, R. I.; Tverdokhlebov, A. V.; Tolmachev, A. A.; Volovenko, Y. M.; Shishkina, S. V.; Shishkin, O. V. Synthesis of condensed tetrahydroimidazo[1,2-a]quinazoline-1,5-dione derivatives. Tetrahedron 2012, 68, 3098-3102.

Dotsenko, V. V.; Krivokolysko, S. G.; Polovinko, V. V.; Litvinov, V. P. On the regioselectivity of the reaction of cyanothioacetamide with 2-acetylcyclo-hexanone, 2-acetylcyclopentanone, and 2-acetyl-1-(morpholin-4-yl)-1-cycloalkenes. Chem. Heterocycl. Com. 2012, 48, 309-319.

Iaroshenko, V. O.; Mkrtchyan, S.; Gevorgyan, A.; Miliutina, M.; Villinger, A.; Volochnyuk, D. M.; Sosnovskikh, V. Ya.; Langer, P. 2,3-Unsubstituted chromones and their enaminone precursors as versatile reagents for the synthesis of fused pyridines. Org. Biomol. Chem. 2012, 10, 890-894.

Gerus, I. I.; Mironetz, R. X.; Kondratov, I. S.; Bezdudny, A. V.; Dmytriv, I. V.; Shishkin, O. V.; Starova, V. S.; Zaporozhets, O. A.; Tolmachev, A. A.; Mykhailiuk, P. K. “Reported, but Still Unknown.” A Closer Look into 3,4-Bis- and 3,4,5-Tris(trifluoromethyl)pyrazoles. J. Org. Chem. 2012, 77, 47-56.

Marchenko, A. P.; Koidan, H. N.; Pervak, I. I.; Huryeva, A. N.; Zarudnitskii, E. V.; Tolmachev, A. A.; Kostyuk, A. N. Direct synthesis of N-phosphanyl-heterocyclic carbenes. Tetrahedron Lett. 2012, 53, 494-496.

Potikha, L. M.; Gutsul, R. M.; Kovtunenko, V. A.; Turov, A.V. Alkylation of 3-Aminoisocarbostyryl Derivatives. Chem. Heterocycl. Com. 2011, 47, 309-315.

Zhersh, S.; Buryanov, V. V.; Karpenko, O. V.; Grygorenko, O. O.; Tolmachev, A. A Library of Conformationally Restricted Saturated Heterocyclic Sulfonyl Chlorides. Synthesis 2011, 3669-3674.

Cherepakha, A.; Kovtunenko, V.O.; Tolmachev, A.; Lukin, O. A one-pot, non-catalytic approach to 1,2,4-benzothiadiazine-1,1-dioxides. Tetrahedron 2011, 67, 6233-6239.

Degtyarenko, A.S.; Tolmachev, A.A.; Volovenko, Y.M.; Synthesis of Heterocyclic Derivatives of Alkyl 2-(Cyanomethyl)-4-methyl-3-quinolinecarboxylates. J. Heterocyclic. Chem. 2011, 48, 1149-1153.

Geraschenko, O.V.; Khodakovskiy, P.V.; Shishkin, O.V.; Mykhailiuk, P.K.; Zaporozhets, O.A.; Tolmachev, A.A. Facile Synthesis of 2-(2-Ethoxy-1,2-dioxoethyl)azoles. Synthesis 2011, 1633-1637.

Grygorenko, O.O.; Radchenko, D.S.; Volochnyuk, D.M.; Tolmachev, A.A.; Komarov, I.V. Bicyclic Conformationally Restricted Diamines. Chem. Rev. 2011, 111, 5506-5568.

Potikha, L.M.; Gutsul, R.M.; Plaskon, A.S.; Kovtunenko, V.A.; Tolmachev, A.A. Condensed Isoquinolines. 37. Heterocyclization Using 3-(Arylamino)- and 3-(Hetarylamino)Isoquinolin-1(2h)-Ones. Chem. Heterocycl. Com. 2011, 47, 342-354.

Ryabukhin, S.V.; Naumchik, V.S.; Plaskon, A.S.; Grygorenko, O.O.; Tomachev, A.A. 3-Haloquinolines by Friedlander Reaction of alpha-Haloketones. J. Org. Chem. 2011, 76, 5774-5781. 

Yarmolchuk, V.S.; Mukan, I.L.; Grygorenko, O.O.; Tolmachev, A.A.; Shishkina, S.V.; Shishkin, O.V.; Komarov, I.V. An Entry into Hexahydro-2H-thieno[2,3-c]pyrrole-1,1-Dioxide Derivatives. J. Org. Chem. 2011, 76, 7010-7016. 

Bogolubsky, A. V.; Ryabukhin, S. V.; Pipko, S. E.; Lukin, O.; Shivanyuk, A.; Mykytenko, D.; Tolmachev, A. A facile synthesis of unsymmetrical ureas. Tetrahedron 2011, 67, 3619-3623

Cherepakha, A.; Kovtunenko, V. O.; Tolmachev, A.; Lukin, O.; Nazarenko, K. G. Facile Synthesis of 4H-1,2,4-Benzothiadiazine-1,1-dioxides. Synth. Commun. 2011, 41, 1977-1989.

Mykhailiuk, P. K.; Shishkina, S. V.; Shishkin, O. V.; Zaporozhets, O. A.; Komarov, I. V. Exploiting morph-DAST mediated ring-expansion of substituted cyclic beta-amino alcohols for the preparation of cyclic fluorinated amino acids. Synthesis of 5-fluoromethylproline and 5-fluoropipecolic acid. Tetrahedron 2011, 67, 3091-3097

Radchenko, D. S.; Tkachenko, A.; Grygorenko, O. O.; Komarov, I. V. Expedient Synthesis of cis- and trans-3-Aminocyclobutanecarboxylic Acids. Synth. Commun.2011, 41, 1644-1649.

Maximov, N. B.; Mykhailiuk, P. K.; Kisel, A. I.; Voitenko, Z. V.; Tolmachev. A. Reaction of Ethyl 5-Acetyl-3,4-dihydropyridine-1(2H)-carboxylate with 1,3-N,N-Bis-nucleophiles: A Facile Access to Novel Pyrimidine Derivatives. Synthesis 2011, 1465-1471.

Levterov, V.; Grygorenko, O. O.; Mykhailiuk, P. K.; Tolmachev, A. Multigram Synthesis of 1-(Difluoromethyl)imidazoles and –benzimidazoles. Synthesis 2011, 1243-1248.

Tolmachova, N. A.; Dolovanyuk, V. G.; Gerus, I.I.; Kondratov, I. S.; Polovinko, V. V.; Bergander, K.; Haufe, G. Synthesis 2011, 1149-1156. http://dx.doi.org/10.1055/s-0030-1258448

Ryabukhin, S. V.; Plaskon, A. S.; Boron, S. Y.; Volochnyuk, D. M.; Tolmachev, A. Aminoheterocycles as synthons for combinatorial Biginelli reactions.. Molecular Diversity 2011, 15, 189-195.

Dacenko, O. P.; Manoylenko, O. V.; Grygorenko, O. O.; Mykhailiuk, P. K.; Volochnyuk, D. M.; Shishkin, O. V.; Tolmachev, A. Improved Synthesis of Monoprotected 5-and 6-Amino-2-azanorbornanes. Synth. Commun. 2011, 41, 981-992.

Bezdudny, A. V.; Alekseenko, A. N.; Mykhailiuk, P. K.; Manoilenko, O. V.; Shishkin, O. V.; Pustovit, Y. M. (5S)-5-(Trifluoromethyl)pyrrolidin-2-one as a Promising Building Block for Fluoroorganic Chemistry. Eur. J. Org. Chem. 2011, 1782-1785.

Yarmolchuk, V. S.; Mykhailiuk, P. K.; Komarov, I. V. Synthesis of beta-fluoro-beta-proline. Tetrahedron Lett. 2011, 52, 1300-1302.

Grygorenko, O. O.; Artamonov, O. S.; Komarov, I. V.; Mykhailiuk, P. K. Trifluoromethyl-substituted cyclopropanes. Tetrahedron 2011, 67, 803-823.

Gorulya, A. P.; Tverdokhlebov, A. V.; Tolmachev, A. A.; Shishkin, O. V.; Shishkina, S. V. The homologous tert-amino effect: a route to fused 2-benzazepine derivatives. Tetrahedron 2011, 67, 1030-1035.

Bezdudny, A. V.; Klukovsky, D.; Simurova, N.; Mykhailiuk, P. K.; Shishkin, O. V.; Pustovit, Y. M. Multigram Synthesis of trans-2-(Trifluoromethyl)cyclopropanamine. Synthesis 2011, 119-122.

Ostrovskyi, D.; Iaroshenko, V. O.; Ali, I.; Mkrtchyan, S.; Villinger, A.; Tolmachev, A.; Langer, P. 3-Methoxalylchromone - A Versatile Reagent for the Regioselective Synthesis of 1-Desazapurine. Synthesis 2011, 133-141.

Denisenko, A. V.; Tverdokhlebov, A. V.; Tolmachev, A. A.; Volovenko, Y. M.; Shishkina, S. V.; Shishkin, O. V. Synthesis of 6-Amino-2-bromo-4-hydroxynicotinaldehyde Derivatives. Synthesis 2011, 251-256.

Iaroshenko, V. O.; Mkrtchyan, S.; Ghazaryan, G.; Hakobyan, A.; Maalika, A.; Supea, L.; Villinger, A.; Tolmachev, A.; Ostrovskyi, D.; Sosnovskikh, V. Y.; Ghochikyanc, T. V.; Langer, P. 3-(Dichloroacetyl)chromone; A New Building Block for the Synthesis of Formylated Purine Isosteres: Design and Synthesis of Fused alpha-(Formyl)pyridines. Synthesis 2011, 469-479.

Kopylova, N. A.; Grygorenko, O. O.; Komarov, I. V.; Groth, U. Synthesis of enantiopure (R,R)- and (S,S)-cis-2,3-propanoprolines. Tetrahedron-Asymm. 2011, 21, 2868-2871.